I've driven over in Florida for 6 holidays, find it very easy and straightforward.
When on freeways/interstates you can overtake on either side.
Familiarise yourself with 4-way junctions.
Be prepared to take a right turn at a junction, even if there is a stop light (treat it as a give way) unless there is a sign stating no turn on red.
When I first drove over there, I had never driven an auto but found it fairly simple. I now drive an auto so it's one less "unfamiliarity" to worry about.
PS, the first time I went, the car rental dude asked who was driving out of the wife and I, I took the keys and without missing a beat, the guy said "if you're not sure what side of the road we drive on,,,, keep the witch in the ditch!",,,, charming!